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Paola Arlotta

molecular biologistresearcher
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Paola Arlotta is the Golub Family Professor of Stem Cell and Regenerative Biology at Harvard University and chair of the Harvard Stem Cell and Regenerative Biology (HSCRB). Her research focuses on the development of neuron types in the cerebral cortex. She is best known for her work using 3D cerebral organoids derived from human induced pluripotent stem cells (iPSCs) to study cortical development in neurodegenerative and neuropsychiatric disorders.

Across 1 conversation, Paola Arlotta ranges across ethics in science, stem cells, organoids. Human brain development takes 9 months in utero and 20 years postnatally, compared to 20 days for mice. Brain organoids, derived from stem cells, mimic aspects of human brain development, aiding in neurodevelopmental disease research.

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The order of cell development in the brain, with neurons forming before glial cells, is crucial for proper brain function.
Paola Arlotta: Brain Development from Stem Cell to Organoid
Technological advances in stem cell biology allow for high-resolution analysis of single cells in organoids, accelerating research.
Paola Arlotta: Brain Development from Stem Cell to Organoid
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